Endometrial tissue from uterine disease-free women does not exhibitaromataseactivity. In contrast, aromataseenzyme activityand mRNA levels are readily detectable in endometriosis. PGE2stimulates both aromatase expression and activity in endometrioticstromal cellsvia promoter II region of the aromatase gene. This results in local production of estradiol, which induces PGE2formation and establishes a positive feedback cycle. This mechanism seems to contribute to continuous local production of estradiol and PGE2.

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ENDOMETRIOSIS LOW PRENATAL TESTOSTERONE > WIDER ENDOMETRIAL- MYOMETIAL JUNCTION (JZ) > HIGHER LEVELS OF OXYTOCIN>GREATER OXYTOCIN RECPTOR RECEPTOR EXPRESSTION IN THE JZ > UTEREINE DYSKINESIS > RETROGRADE MENSES > INFERTILITY > GREATER RISK OF PRE-TERM LABOR

Endometriosis is driven by relatively low levels of prenatal and postnatal testosterone. Testosterone affects the developing hypothalamic–pituitary–ovarian (HPO) axis, and at low levels, it can result in an altered trajectory of reproductive and physiological phenotypes that can mediate the...

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