Endometriosis is driven by relatively low levels of prenatal and postnatal testosterone. Testosterone affects the developing hypothalamic–pituitary–ovarian (HPO) axis, and at low levels, it can result in an altered trajectory of reproductive and physiological phenotypes that can mediate the...
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Like other organs, organized contractions occur in the uterus. In the nonpregnant uterus, three patterns of contractility are typically encountered throughout the menstrual cycle. First, under the influence of E2 during the late follicular phase, uterine contractions are mainly retrograde...
Virtually all 1st world countries guarantee women access to IVF, save one the US. Insurance covers 4 cycles in France and Belgium, 3 in the UK. In Germany hormonal therapies for the support of ovum maturation are covered completely...
Endometriosis is driven by relatively low levels of prenatal and postnatal testosterone. Testosterone affects the developing hypothalamic–pituitary–ovarian (HPO) axis, and at low levels, it can result in an altered trajectory of reproductive and physiological phenotypes that can mediate the...
Increased GnRH pulse generation in the hypothalamus increases LH pulse frequency, amplitude as well as 24-hour mean serum concentrations. Increased luteinizing hormone (LH) secretion together with enhanced theca cell responsiveness drives the production of excess androgen. The increased androgen...
Endometrial tissue from uterine disease-free women does not exhibitaromataseactivity. In contrast, aromataseenzyme activityand mRNA levels are readily detectable in endometriosis. PGE2stimulates both aromatase expression and activity in endometrioticstromal cellsvia promoter II region of the aromatase gene. This results in...
Women suffering from infertility in association with mostly mild endometriosis were subjected to vaginal sonography of uterine peristalsis during the menstrual period, the early, mid- and late follicular phases, and the mid-luteal phase of the menstrual cycle. The data...
Societal pressure to help young women transition can create a major medical dilemma. Before any prescribed course is followed, a qualified psychiatrist should be consulted. The use of super physiological doses of androgens to facilitate transition comes with significant...
I have had the good fortune to work on reproductive issues in nearly every major country in the world. Virtually all, save the United States have enacted legislation that both protects women’s rights and maintains and ethical medical standards....