Archive for Category: MIS analysis

ENDOMETRIOSIS RELATED PRE-TERM LABOR

Approximately 15 million preterm neonates are born annually and more than 1 million die from subsequent complications within the following 5 years. Adverse outcomes related to prematurity span a spectrum that includes neurodevelopmental (e.g., neurocognitive impairment, cerebral palsy, hearing...

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ENDOMETRIOSIS LOW PRENATAL TESTOSTERONE > WIDER ENDOMETRIAL- MYOMETIAL JUNCTION (JZ) > HIGHER LEVELS OF OXYTOCIN>GREATER OXYTOCIN RECPTOR RECEPTOR EXPRESSTION IN THE JZ > UTEREINE DYSKINESIS > RETROGRADE MENSES > INFERTILITY > GREATER RISK OF PRE-TERM LABOR

Endometriosis is driven by relatively low levels of prenatal and postnatal testosterone. Testosterone affects the developing hypothalamic–pituitary–ovarian (HPO) axis, and at low levels, it can result in an altered trajectory of reproductive and physiological phenotypes that can mediate the...

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