The endometrial-myometrial junction EMJ is the transitional zone between the mucous membrane that is the endometrium and the outer smooth- muscle layer of the myometrium. The EMJ is structurally distinct from other mucosal – muscle interfaces within the human...
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Uterine leiomyomas (fibroids) are benign smooth muscle tumors originating from the uterus, and affect up to 77% of all reproductive-age women in the United States. No effective treatments other than myomectomy or hysterectomy exist, and approximately 200,000 hysterectomies are...
Endometriosis is driven by relatively low levels of prenatal and postnatal testosterone. Testosterone affects the developing hypothalamic–pituitary–ovarian (HPO) axis, and at low levels, it can result in an altered trajectory of reproductive and physiological phenotypes that can mediate the...
Like other organs, organized contractions occur in the uterus. In the nonpregnant uterus, three patterns of contractility are typically encountered throughout the menstrual cycle. First, under the influence of E2 during the late follicular phase, uterine contractions are mainly retrograde...